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师资队伍
教授

姓名:

魏彦明

性别:

职务:

职称:

教授

学历:

博士研究生

导师类型:

博导兼硕导

办公电话:

邮箱:

weiym@gsau.edu.cn

个人简介
魏彦明,男,汉族,1963年11月出生,甘肃省通渭县人,中共党员,博士,二级教授,博士研究生导师,国家现代农业产业技术体系--肉牛牦牛产业技术体系疾病防控研究室传统中兽医兽药岗位专家。兼任中国兽药典委员会委员、农业部农村部兽药评审专家、农业农村部中药GCP专家,中国畜牧兽医学会中兽医学分会副理事长。任《中国农业百科全书.中兽医卷》副主编及方剂学分支主编、《中国兽医学报》《中兽医药杂志》《中兽医学杂志》编委。长期从事中兽医学和临床兽医学的教学、科学研究、社会服务和技术推广工作,主持和完成国家自然科学基金面上项目5项,国家自然科学基金地区项目1项,国家公益性行业(农业)科研专项“中兽医关键技术研究与示范”项目“牛重要脾胃病辨证施治关键技术研究与示范”等10余项。获省部级科奖励5项。主编、参编教材专著10余部,在国内外期刊发表科技论文100多篇,已培养毕业学术型博士研究生20余名,兽医专业博士5名,硕士研究生60余名。
教育访学经历
2000.09-2003.06,甘肃农业大学,动物医学院临床兽医学专业毕业,博士学位;
1990.08-1993.07,中国农业科学院研究生院,临床兽医学专业中兽医学毕业,硕士学位;
1982.09-1986.07,甘肃农业大学,兽医系兽医系兽医学专业毕业,学士学位;
研究方向
中兽医学基础理论、中药药理学、新中兽药研发及应用和畜禽疾病中兽药防治等。
奖励与荣誉
[1] 主持完成的“当归及其不同炮制品药效改变的物质基础、质量标准和药效学研究”,2018年获甘肃省自然科学奖二等奖(甘肃省人民政府,排名第1);
[2] 主持完成的“基于现代药学的五种甘肃地产中药应用于畜禽生产的关键技术研究”,2014年获甘肃省科技进步二等奖(甘肃省人民政府,排名第1);
[3] 参与完成的“主动适应地方社会经济发展需求,培养大量高素质创新型人才-甘肃农业大学学生科研训练计划的探索、实践与成效”,2014年获甘肃省教学成果奖省级一等奖(甘肃省科学成果奖评审委员会,排名第3);
[4] 参与完成的“动物生物粘合剂的研究与应用”,2016年获甘肃省科技进步三等奖(甘肃省人民政府,排名第5);
[5] 2016年获得甘肃省优秀学位论文(博士论文)优秀指导教师(甘肃省学位委员会、甘肃省教育厅,唯一指导教师);
[6] 2018年获得甘肃省优秀学位论文(硕士论文)优秀指导教师(甘肃省学位委员会、甘肃省教育厅,唯一指导教师);
[7] 参与完成的“鼢鼠类防控关键技术研究、集成与应用”,2020年获甘肃省科技进步二等奖(甘肃省人民政府,排名第3)。
教学工作
主讲本科生 “中兽医学”、“中医基础理论”、“新兽药研发与注册”和研究生 “中兽医学进展”、“兽医中药学”与“中药药理学专题”等课程。
在研项目
1. 国家现代农业产业技术体系肉牛牦牛产业技术体系疾病防控室传统中兽医兽药防治岗位专家,2017年至今。
2. 国家自然科学基金地区联合基金重点项目:利用宁夏道地中药防治奶牛隐性乳房炎的组方筛选及机制研究(U21A20262)子课题-当归补血汤加减方对产后奶牛隐性乳房炎防治作用的物质基础、机理研究及补中益气汤、黄芪生脉饮防治乳房炎的物质基础研究(U21A20262-12022.1-2025.12),经费75.80万元。
3. 国家自然科学基金地区基金项目,中兽医学湿热泄泻肠道菌群-ILC3s互作机制及芍药汤干预作用研究,(项目批准号:2060812,2021.1-2024.12)。
4. 防治畜禽腹泻新中兽药鹳榆止泻散和颗粒剂的创制与产业化(甘肃省教育厅产业支撑项目),经费80.00万元,2021.7-2023.7。
5. 牛羊肉中主要化学性危害物非靶向筛查和精准识别技术应用示范02(国家重点研发项目子课题),经费10万元,2020.7-2024.12。
代表性文章
1.期刊论文
[1]Yao W, Zhang Y, Zhang W, Wen Y, Yang R, Dong J, Zhang X, Hua Y, Ji P, Wei Y*. Pathological mechanism of intestinal mucosal barrier injury of large intestine dampness-heat syndrome rats and the protective effect of Yujin powder [J]. Res Vet Sci. 2022, 152: 485-496.
[2]Zhang X, Jia Y, Yuan Z, Wen Y, Zhang Y, Ren J, Ji P, Yao W, Hua Y, Wei Y*. Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process [J]. Phytomedicine. 2022,97:153920.
[3]Wen Y, Zhang W, Yang R, Jiang L, Zhang X, Wang B, Hua Y, Ji P, Yuan Z, Wei Y*, Yao W. Regulation of Yujin Powder alcoholic extracts on ILC3s-TD IgA-colonic mucosal flora axis of DSS-induced ulcerative colitis [J]. Front Microbiol. 2022,13:1039884.
[4]Li J, Zhang R, Yang H, Wei Y*. Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation. Pharm Dev Technol. 2022 Sep;27(7):759-765.
[5]Li J, Chang Y, Yang S, Zhou G, Wei Y. Formulation enhanced the stability of Foot-and-mouth virus and prolonged vaccine storage [J]. Virol J. 2022,19(1):207.
[6]Jing Z, Ji P, Wei Y, Hao F, Wei Y*. Isolation and identification of a novel canine parvovirus type 2c strain in domestic cats in Dalian, China [J]. Front Vet Sci. 2022,13;9:1001604.
[7]He J, Shang X, Dai L, Yang X, Li B, Wei Y*, Zhang J, Pan H. Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species [J]. Front Vet Sci. 2022;9:882060. [8]Zhang X, Jian Y, Guo Z, Duo H, Wei Y*. Development of a Triplex Real-Time Pcr Assay to Detect Echinococcus Species in Canid Fecal Samples [J]. J Parasitol. 2022 Jan 1;108(1):79-87.
[9]Ji P, Li CC, Wei YM*, Hua YL, Yao WL, Wu FL, Zhang XS, Yuan ZW, Zhao NS, Zhang YH, Wen YQ. A new method providing complementary explanation of the blood-enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue-integrated metabolomics and confirmatory analysis [J]. Biomed Chromatogr. 2022 Feb;36(2):e5252.
[10]Hua YL, Ma Q, Zhang XS, Jia YQ, Peng XT, Yao WL, Ji P, Hu JJ, Wei YM*. Pulsatilla Decoction Can Treat the Dampness-Heat Diarrhea Rat Model by Regulating Glycerinphospholipid Metabolism Based Lipidomics Approach [J]. Front Pharmacol. 2020,11:197.
[11]Hua YL, Jia YQ, Zhang XS, Yuan ZW, Ji P, Hu JJ, Wei YM*. Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5 [J]. Biomed Pharmacother. 2021 May;137:111320.
[12]Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y*. Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism [J]. J Ethnopharmacol. 2020 Sep 15;259:112872.
[13]Gao X, Zhang L, Zhou P, Zhang Y, Wei Y, Wang Y*, Liu X. Tandem Mass Tag-Based Quantitative Proteome Analysis of Porcine Deltacoronavirus (PDCoV)-Infected LLC Porcine Kidney Cells [J]. ACS Omega. 2020 Sep 8;5(35):21979-21987.
[14]Gao X, Liu X, Zhang Y, Wei Y, Wang Y*. Rapid and visual detection of porcine deltacoronavirus by recombinase polymerase amplification combined with a lateral flow dipstick. BMC Vet Res [J]. 2020 May 7;16(1):130.
[15]Yang M, Wei Y*, Ashokkumar M, Qin J, Han N, Wang Y. Effect of ultrasound on binding interaction between emodin and micellar casein and its microencapsulation at various temperatures [J]. Ultrason Sonochem. 2020 Apr;62:104861.
[16]Yuan Z, Yang L, Zhang X, Ji P, Wei Y*. Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice [J]. Biomed Pharmacother. 2020 Jan;121:109638.
[17]Ji P, Li C, Wei Y*, Wu F, Liu S, Hua Y, Yao W, Zhang X, Yuan Z, Wen Y. Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology [J]. Pharm Biol. 2020 Dec;58(1):1167-1176.
[18]Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yongli Hua, Yanming Wei*. (2019) Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function [J]. Frontiers in Pharmacology. 10, 1354.
[19]Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yanming Wei*. (2019) Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice [J]. Biomedicine & Pharmacotherapy, 121(109638).
[20]Qi Ma, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Xiaosong Zhang, LiJia Zhong, Yanming Wei*. (2019) Effects of Tao-Hong-Si-Wu decoction on acute blood stasis in rats based on a LC-Q/TOF-MS metabolomics and network approach [J]. Biomedical Chromatography, 32(4).
[21]Peng Ji, Yanming Wei*, Yongli Hua, Xiaosong Zhang, Wanling Yao, Qi Ma, Ziwen Yuan,Yanqiao Wen, Chaoxue Yang. (2018) A novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products [J]. Journal of Ethnopharmacology, 211, 101–116
[22]Ziwen Yuan, Lijia Zhong, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Xiaosong Zhang, Yanqiao Wen, Lihong Yang, Yanming Wei*. (2019) Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products [J]. Biomedical Chromatography, 33(4).
[23]Xiaosong Zhang, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang, Yanming Wei*. (2018) Urinary metabolomics study the mechanism of Taohong Siwu Decoction intervention in acute blood stasis model rats based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry [J]. Journal of Chromatography B, 1074-107
[24]Yongli Hua, Qi Ma, Xiaosong, Zhang, Wanling Yao, Peng Ji, Junjie Hu, Yanming Wei*. (2019) Urinary metabolomics analysis reveals the effect of volatile oil from Angelica sinensis on LPS-induced inflammation rats. Biomedical Chromatography, 33(2).
[25]Qiwei Chen, Xiongwei Gong, Fuying Zheng, Peng Ji, Ziwen Yuan, Yongsheng Liu, Yanming Wei*. (2019) Prevalence and Characteristics of Quinolone Resistance in Salmonella Isolated from Retail Foods in Lanzhou, China. Journal of Food Protection, 82(9): 1591-1597.
[26]Yongli Hua, Qi Ma, Wei Li, Xiaosong Zhang, Xiaohua Cheng, Yaqian Jia, Xiaoting Peng, Wanling Yao, Peng Ji, Junjie Hu, Yanming Wei*. (2019) Metabolomics analysis of Pulsatilla decoction on treatment of wetness-heat-induced diarrhea in rats based on UPLC-Q/TOF–MS/MS [J]. Biomedical Chromatography. 33(11):e4629.
[27]Wanling Yao, Chaoxue Yang, Yanqiao Wen, Wangdong Zhang, Xiaosong Zhang, Qi Ma, Peng Ji,Yongli Hua, Yanming Wei*. (2017) Treatment effects and mechanisms of Yujin Powder on rat model of large intestine dampness-heat syndrome [J]. Journal of Ethnopharmacology, 202: 265-280.
[28]Yongli Hua, Wangling Yao, Peng Ji, Yanming Wei*. (2017) Integrated metabonomic–proteomic studies on blood enrichment effects of Angelica sinensis on a blood deficiency mice model. Pharmaceutical Biology, 55(1): 853-863.
[29]Jian Li, Yongli Hua, Peng Ji, Wanling Yao, Haifu Zhao, Lijia Zhong, Yanming Wei*. (2016) Effects of volatile oils of Angelica sinensis on an acute inflammation rat model [J]. Pharmaceutical Biology, 54(9), 1881-1890.
[30]Tao Wang, Hongguo Sun, Yongli Hua, Pengling Li, Yanming Wei*. (2016) Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model [J]. Chinese Journal of Natural Medicines, 14(3), 210-219.
[31]Lijia Zhong, Yongli Hua, Peng Ji, Wanling Yao, Wenquan Zhang, Jian Li, Yanming Wei*. (2016) Evaluation of the Anti-inflammatory Effects of Volatile Oils from Processed Products of Angelica sinensis radix by GC-MS-Based Metabolomics [J]. Journal of Ethnopharmacology, 191, 195-205.
[32]Ruiqiong Wang, Guotai Wu, Lidong Du, Jing Shao, Fenglin Liu, Zhijun Yang, Dongling Liu, Yanming Wei*. (2016) Semi-bionic extraction of compound turmeric protects against dextran sulfate sodium-induced acute enteritis in rats [J]. Journal of Ethnopharmacology, 190: 288-300.
[33]Wenquan Zhang, Yongli Hua, Man Zhang, Peng Ji, Jinxia Li, Ling Zhang, Peng-ling Li and Yanming Wei*. (2015) Metabonomic analysis of the anti-inflammatory effects of volatile oils of Angelica sinensis on rat model of acute inflammation [J]. Biomedical Chromatography, 29: 902-910.
[34]Pengling Li, Hongguo Sun, Yongli Hua, Peng Ji, Ling Zhang, Jinxia Li, Yanming Wei*. (2015) Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model [J]. Journal of Ethnopharmacology, 166261-269.
[35]Yongli Hua, Peng Ji, Ziyu Xue, Yanming Wei*. (2015) Construction and analysis of correlation networks based on gas chromatography-mass spectrometry metabonomics data for lipopolysaccharide-induced inflammation and intervention with volatile oil from Angelica sinensis in rats [J]. Molecular BioSystems, 11: 3174-3187.
[36]Wanling Yao, Ling Zhang, Yongli Hua, Peng Ji, Pengling Li, Jinxia Li, Lijia Zhong, Haifu Zhao, Yanming Wei*. (2015) The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach [J]. International Immunopharmacology, 29: 269-277.
[37]Junhu Su, Weihong Ji, Yanping Zhang, Dianne M. Gleeson, Zhongyu Lou, Jing Ren, Yanming Wei*. (2015) Genetic diversity and demographic history of the endangered and endemic fish (Platypharodon extremus): implications for stock enhancement in Qinghai Tibetan Plateau [J]. Environmental Biology of Fishes, 98(3).
[38]姚万玲,文艳巧,华永丽,纪鹏,魏彦明*.郁金散对大肠湿热证大鼠回肠、结肠黏膜SIgA和炎性因子的影响[J].畜牧兽医学报,2019,50(10):2147-2155.
[39]杨丽宏,袁子文,纪鹏,张晓松,华永丽,魏彦明*.黄连解毒汤中13种活性成分的HPLC检测及其有效部位的筛选[J].中草药,2019,50(16):3794-3801.
[40]刘学楠,贾娅倩,华永丽,张晓松,纪鹏,姚万玲,魏彦明*.苦豆子不同提取物对小鼠急性毒性的“谱-毒”关系研究[J].中草药,2019,50(11):2656-2664.
[41]张亚辉,姚万玲,文艳巧,华永丽,纪鹏,魏彦明*.郁金散对大肠湿热证大鼠血清免疫球蛋白与抗氧化相关因子的调节作用[J].畜牧兽医学报,2018,49(9):2044-2053.
[42]张晓松,马琪,文艳巧,张亚辉,何建,尹博,姚万玲,袁子文,纪鹏,华永丽,魏彦明*.苦豆草治疗大肠湿热证大鼠血清代谢组学研究[J].药学学报,2018,53(1):111-120.
[43]文艳巧,姚万玲,杨朝雪,马琪,张晓松,纪鹏,华永丽,魏彦明*.郁金散对大肠湿热证模型大鼠血清及肠道组织胃肠激素的影响[J].畜牧兽医学报,2017,48(6):1140-1149.
2.专著
[1] 赵兴绪,魏彦明主编《畜禽疾病处方指南》,金盾出版社,2003年1月第一版.
[2] 普通高等教育“十二五”规划教材《中兽医学》,副主编,科学出版社,2013.7.
[3] 《中兽医验方与妙用精编》,副主编,化学工业出版社,2019.6.