在研项目
[1] 甘肃省青年科技基金计划，黄连解毒汤治疗溃疡性结肠炎有效部位药效成分筛选及其分离纯化研究, 在研, 主持
[2] 甘肃省高等学校创新基金项目，基于系统药理学的柴胡保肝作用潜在活性成分筛选及其作用机制研究, 在研, 主持
[3] 甘肃农业大学公招博士科研启动项目，四逆散治疗细菌性腹泻疗效及其药效物质基础研究, 在研, 主持
[4] 国家自然科学基联合基金项目，利用宁夏道地中药防治奶牛隐性乳房炎的组方筛选及机制研究, 在研, 参与
[5] 国家自然科学基金地区科学基金项目，当归补血汤通过调控HIF-1α/VEGF信号通路干预气虚血瘀型肺间质纤维化的物质基础与机制研究，在研, 参与
1.期刊论文
[1] Yuan Ziwen, Yang Lihong, Zhang Xiaosong, Ji Peng, Hua Yongli, Wei Yanming*. Mechanism of Huang-lian-Jie-du
decoction and its effective fraction in alleviating acute ulcerative colitis in mice: regulating arachidonic acid metabolism and glycerophospholipid metabolism [J]. Journal of Ethnopharmacology. 2020. 259, 112872, 1-13. Doi: 10.1016/j.jep.2020.112872.
[2] Yuan Z.W., Yang L.H., Zhang X.S., et al. Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction
on ulcerative colitis and its regulation on intestinal flora in colitis mice. Biomedicine & Pharmacotherapy. 2020, 121: 109638. Doi: 10.1016/j.biopha.2019.109638
[3] Yuan Z.W., Yang L.H., Zhang X.S., et al. Huang-Lian-Jie-Du decoction ameliorates acute ulcerative colitis in mice
via regulating NF-κB and Nrf2 signaling pathways and enhancing intestinal barrier function. Front. Pharmacol. 2019, 10: 1354. Doi: 10.3389/fphar.2019.01354
[4] Yuan Z.W., Zhong L.J., Hua Y.L., et al. Metabolomics study on promoting blood circulation and ameliorating blood
stasis: Investigating the mechanism of Angelica sinensis and its processed products. Biomedical Chromatography. 2019; e4457. Doi: 10.1002/bmc.4457
[5] 袁子文, 钟立甲, 纪鹏, 等. 当归干预血瘀证大鼠血浆代谢组学研究[J]. 天然产物研究与开发, 2018, 30: 559-567.
[6] 袁子文, 李平花, 孙普, 等. 一株A型口蹄疫流行毒株全序列的测定及其全长感染性克隆的构建[J]. 微生物学通报, 2016, 43(9):
2019-2027.
[7] 杨丽宏, 袁子文, 纪鹏, 张晓松, 华永丽, 魏彦明. 黄连解毒汤中13种活性成分的HPLC检测及其有效部位的筛选[J].中草药, 2019, 50(
16): 3794-3801.
[8] Yongli Hua*, Yaqian Jia, Xiaosong Zhang, Ziwen Yuan, Peng Ji, Junjie Hu, Yanming Wei. Baitouweng Tang ameliorates
DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5. Biomedicine & Pharmacotherapy, 2021, 137.111320.
[9] Yaqian Jia; Ziwen Yuan; Xiaosong Zhang; Jiaqi Dong; Xuenan Liu; Xiaoting Peng; Wanling Yao; Peng Ji; Yanming Wei;
Yongli Hua*; Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota, Journal of Ethnopharmacology, 2020, 255.112775.
